Research in the Brisson laboratory lies at the interface between evolutionary biology, microbial ecology, and molecular genetics. We use molecular techniques, evolutionary theory, and computer modeling to elucidate the evolutionary forces that have shaped the history of populations. Additionally, we use molecular genetics and classic ecology to discover the interactions that govern the current distribution and abundance of populations and genotypically distinct lineages within populations. Our research focuses on interactions between eukaryotes and microbes of interest in public health (Lyme disease bacteria). The approaches used in the Brisson lab can be used to address a wide variety of fundamental issues in evolutionary biology and ecology.